One shopkeeper in st Mary's street who wished to remain anonymous said: "Everybody's shocked in this area by what's happened, the brutality of it.
"We've had murders here it does happen but it happens everywhere, in Shirley and in Millbrook, everywhere.
"I've worked in this area for 20 years, I really like this area, it's a real close-knit community."
Reports from shopkeepers in the area is that the police cordon on st Mary's street is expected to be up until Monday.
Forensic experts hunt through the rubbish near the scene of the shooting for clues.
Many people have been expressing their shock at was has happened.
Mohamed Mohamud from the Hampshire Somali Community centre in James Street said: "A lot of people are shocked by what's happened here.
"I've got nothing but positive praise for this area."
Hampshire Poilce statement added: "Police are appealing for anyone who was in Ladbrokes on St Mary Street between 9am and 11am on Saturday, April 20, or who may have any other information to contact the Hampshire Major Investigation Team by phoning 101, quoting Operation Emetic.
"Mini-Com users can call the police on 18001 101. Information can be given anonymously by calling the Crimestoppers charity on 0800 555 111.
Police are now appealing for any witnesses who may have been in the Ladbrokes betting shop around the time of the shooting.
Chief Insp Dibdin said: “We understand the public may have some concerns of safety due to the nature of this incident.
"We do not believe the public are in any danger as we are following a number of lines of enquiry that cause us to believe at this time this is a drug related incident where the victim and suspects were known to each other is some way, and this incident has occurred as a result of their criminal activity.
"We will continue to have a police presence in and around the St Mary’s area while the investigation at the premises continues.”
Chief Inspector Craig Dibdin, pictured below, from Southampton Central Police Station has issued a statement.
Police have also moved to allay public fears following the shooting.
A statement from Hampshire Police says that it is believed these individuals were all around the scene at the time of the incident.
Those being interviewed are a 36-year-old female, a 21-year-old male, a 41-year-old male and two 18-year-old males.
They say that five people have now been arrested, on suspicion of murder, in connection with the incident
Police have also arrested more people in connection with the shooting.
A full post-mortem is taking place this morning say police.
A cordon set up at the bottom of st Mary's street next to City College has been taken down .
Shopkeepers are opening up again after their businesses were forced to close during the day.
The deceased died following a gun shot from what is believed to be a hand gun. The gun has no yet been recovered.
He was Jamal Jones, 23, unemployed of Lyon Street, Southampton.
Police have now named the victim of the shooting in St Mary's yesterday.
A ST GEORGE'S day parade due to take place in Southampton today has been cancelled in the wake of yesterday's shooting.
The traditional Southampton Scouts parade, centred on St Mary's Church, has been called off because of the ongoing police murder investigation.
A police statement said: "A 36-year-old female and a 41- year-old male were arrested at the scene and are being interviewed in connection with the incident.
"Police are still conducting enquiries to establish how many other people are connected with the incident.
"It is believed the individuals involved were all known to each other and this is being treated an isolated incident.
The victim died following a gunshot wound. No further details about the deceased are available at this time as formal identification has not taken place yet and next of kin still need to be informed.
"Anyone with any information is asked to contact the Hampshire Major Investigation Team by phoning 101, quoting Operation Emetic.
"Mini-Com users can call the police on 18001 101. Information can be given anonymously by calling the Crimestoppers charity on 0800 555 111."
Poilce said all those involved in the incident knew each other.
Tonight the blue and white police cordon in St Mary Street remains in place as officers continue their murder investigation.
But the police spokeswoman added: "We are actively seeking other suspects.
"They do not pose a further threat to the public - I believe there are two further suspects police are seeking."
Officers have said that while two people are in custody they are hunting two other suspects in connection with the incident.
Police have also revealed a new twist in their investigation.
Both the man and the woman are being questioned over the shooting by detectives at a city police station tonight.
Both were arrested by officers shortly after police arrived at the scene of killing earlier today, said police.
They added that the woman arrested was aged 36.
The man being held is 41 years old, said police.
Officers have revealed that man and woman have been arrested in connection with the shooting.
A spokeswoman for police confirmed that the incident was now being treated as a murder inquiry.
Hampshire police tonight has revealed more details of the city shooting drama today.
Saman Kadiri, 29, who owns Kocher Hairdreseers, in St Mary Street, added: "This is unacceptable - it has come as a shock."
Owner of Master Friers, a takeaway business, Litu Khan said: "It's normally alright round here but I think it will affect people because lots of people are worried about what has happened, what's going on and why.
"People want answers. "
This is the moment emergency services battled to save life of the Southampton shooting victim as he was rushed into an ambulance.
He died later at Southampton General Hospital.
Dramatic footage has emerged of the victim being rushed into a ambulance after the shooting.
Police forensic experts prepare to carry out investigations.
One police officer at the scene said the cordon would remain in place for some time.
He added that a forensic examination was being carried out inside the flat.
He added that a special police team may conduct a finger-tip search on the street around the flat in the hunt for clues.
Police have now moved the cordon back about 20 m to allow vans from the market to get out.
A 74-year-old woman said: "I've been here 45 years and I thought this area was getting better but it's not.
"I've never seen so many police - not evene at a football match."
A local cab driver, aged 30, said: "I had a lump in my throat when I was told what had happened.
"The first thing you think of is it could have been my family - anybody could have been walking by."
"It's a tragedy that a life has been lost regardless of whatever is behind it."
Police meet outside murder scene before entering flat where shooting took place.
Carer Tina Driscoll, 44, from Radstock Road, Woolston, said: "It's scary and soemthing you see in a movie and don't expect it to be here.
"It's frightening especially when you see the policemen's guns because we are not used to that."
Police meeting at the scene of the shooting
Echo reporter Emma Streatfield has sent this video of the scene this afternoon.
For an overview of the gun drama that has shocked a community click here
One 26-year-old man at the scene said:
"I noticed police out there with machine guns.
"I came down and spoke to a police officer and he said somebody has been shot in the head in the flat opposite and that no one was allowed in or out of the road for their own safety."
"I didn't hear any shots but saw police inside the flat doing forensics."
Anyone with any information is asked to contact the Hampshire Major Investigation Team by phoning 101, quoting Operation Emetic.
Mini-Com users can call the police on 18001 101. Information can be given anonymously by calling the Crimestoppers charity on 0800 555 111
Police have issued an appeal for witnesses
Full police statement:
A man was found injured in an address in St Mary Street with what appeared to be gunshot wounds.
The man was taken to Southampton General Hospital in a life threatening condition where he has died.
CID have started a major investigation and are at the scene to identify possible witnesses and preserve evidence.
There are road closures and diversions in the area around St Mary’s Street.
The shootiing victim has died, according to Hampshire Police.
A resident sent in this video just minutes after the shooting.
Market worker Carl Lowes, 20, from the Holyrood Estate, said: "I asked police what happened and he said someone has been shot in the head."
One witness told Daily Echo reporter Emma Streatfield: "Two police turned up and another one with a pistol.
"Four or five vans came down and parked outside and set up a cordon.
"Next an amublance arrived and a man was brought out being given CPR and taken into an ambulance which sped off."
Armed police on the street at St Marys
The moment police arrested a suspect
Echo photographer Paul Collins sent this picture of the police cordon.
Another man, who did not want named, said: "I live next door but was out at the time.
"My step daughter rang me to say someone's been shot.
"We're not allowed anywhere near it."
One 25-year-old resident in a flat opposite the drama said: "I've heard somebody has been shot in the head.
"I saw the ambulance pull up outside and there were ten different police vehicles with armed officers and dogs."
According to Echo staff at the scene police taken man in handcuffs into a police van.
This is the moment when an injured man was rushed into an ambulance.
Witness Mr Kempson said: "It's quite wierd, you do not expect this sort of thing on your own door step.
"It's like something off the news and not something you expect to happen round here."
The incident comes as police continue with Operation Fortress across Southampton - an on going crackdown on violent drug related crime across Southampton.
Aaron Kempson, 21, said there are lots of armed police officers at the scene between the Best One and Premier Store in St Mary Street.
"It's been really crazy and quite scary. Looking out the window there are lots of police officers around," said resident Amy Rose.
Resident Amy Rose, 20, said she had seen someone put on a stretcher and then into an ambulance.
Residents and businesses have been told to remain indoors, said a witness.
Armed police surround the scene with officers talking to witnesses in surrounding properties.
A man of unknown identity has been rushed to hospital following an incident near to the St Marys Market, said one witness.
Residents have reported seeing a man being carried out a house in the area.
Police have closed off St Mary Street but have not said any more.
Police are reported to be carrying out house to house investigations in the hunt for man.
Armed police have descended on the St Mary's area following the incident this morning.
Police have launched a manhunt after a shooting in Southampton today.